WHEN TO START INSULIN IN DIABETICS AND HOW TO ADJUST? Insulin is usually recommended as the initial therapy for diabetes if a person's HbA1c level at diagnosis is greater than 10% or if someone's fasting blood glucose level is consistently above 250 mg/dl ALSO, Insulin should be initiated when A1C is ≥7.0% after 2–3 months of dual oral therapy. The preferred regimen for insulin initiation in type 2 diabetes is once-daily basal insulin . In addition to timely initiation, rapid titration of the dose is indispensable for successful insulin therapy. Let's BE FAMILIAR WITH SOME BRAND NAMES OF INSULIN: Let's SEE FOR EXAMPLE, HOW YOU INITIATE AND ADJUST NovoLog ® Mix 70/30